A simplified prognostic scoring and grading system for Fournier’s gangrene

Background: Fournier’s gangrene is life threatening, necrotizing fasciitis, affecting external genetalia of male greater than female with mortality 7 to 53%. Fournier gangrene severity, LRINR and LNR scoring used to evaluate morbidity and mortality. Aim and objective of our study was to simplify a system, especially for Indian peripheral health centers which can predict mortality, morbidity.Methods: This study was conducted in department of surgery of Teerthankar Mahaveer University. Body mass index, blood urea nitrogen and patient demography used to develop the scoring system with minimum and maximum points and correlated our results.Results: Our simplified scoring system also has a direct bearing on mortality, morbidity, recovery and hospital stay. In our study 3 male and 2 females died.Conclusions: Simplified scoring and grading system will be helpful in predicting the morbidity and mortality, early surgical intervention, hospital stay, time for reconstruction.

Morphometric Study Of Inguinal Canal On Cadaver

Background: The inguinal canal is an oblique intermuscular passage lying above the medial half of the inguinalligament. Its size and form vary with age and sex, although it is present in both sexes, it is most well developedin male. The inguinal canal in both sexes has been studied by many workers both in India and in other countries.It is observed that the inguinal hernia and recurrence of hernia after surgery is very common in the kosi regionof Bihar. This observational study may help the surgeons during the operation of inguinal hernia.Materials and Methods: Present study conducted at the department of Anatomy, Katihar medical college andhospital Katihar and Lord Buddha Kosi Medical College, Saharsa during the period of 2010 to 2016. The cadaverprovided for dissection to the student of first professional MBBS, are selected for the study. Cadavers withinjured groin region are not taken for the study. Measurements were done by stainless steel scale and spreadingcalliper during dissection of groin region.Results: Anatomy of inguinal canal, superficial inguinal ring, the deep inguinal ring and the related structureswas studied in details in 50 cadavers in the dissection hall at the time of dissection. During this study I havefound that the average length of inguinal canal in the male was 38.35 mm. The longest diameter of deep inguinalring is 13 mm and smallest diameter is 9 mm. The average measurement of superficial inguinal ring was 12mmalong the base and 24mm from apex to base.Conclusion: At the end of the study I have found a little variation from the established facts related to diameter ofsuperficial inguinal ring, position of deep inguinal ring and direction of fibres of external oblique aponeurosis.

Morphological And Morphometrical Analysis Of Foramen Magnum: An Anatomical Study

Background: Foramen magnum (FM) is an important landmark of the skull base and is of particular interest foranthropology, anatomy, forensic medicine and other medical field. It is one of several oval or circular aperturesin the base of the skull, through which medulla oblongata is transmitted. Variations of the shape of FM have gotdiagnostic clinical and radiological importance. The dimensions of FM have clinical importance because thevital structures that pass through it may suffer compression as in cases of FM achondroplasia and FM brainherniation, so this study aimed to access its diameter and determining its various shape.Materials and Methods: Study sample consisted of 75 dry adult human skull of unknown sex, free from anypathology and collected from Department of Anatomy, P.D.U. Medical College, Rajkot, Gujarat and Americaninternational institute of medical sciences, Udaipur, Rajasthan, India.Results: The FM was observed to have round shape in 8%, egg shape in 9.33% tetragonal in 25.33%, oval in33.33%, irregular in 2.67%, hexagonal in 8% and pentagonal in13.33% of the cases. The mean antero-posteriorand transverse diameter of the FM was recorded as 34.00+/- 2.38 mm and 28.68+/-1.88 mm respectively. TheMaximum diameter of antero-posterior and transverse diameter was recorded 39.53mm and 32.14mmrespectively. The Minimum diameter of antero-posterior and transverse diameter was recorded 28.72 mm and23.54 mm respectively.Conclusion: Though the present study has a limitation as the exact age and sexes of skull were not determined,this study may provide an important reference and the measurements may be used as a data for the descriptionof normal morphological variants of FM. The present study will be of useful to the neurosurgeons and is alsohelpful to the anthropologists and clinical anatomists.

Rasayana: The Rejuvenating Remedy For Health

Gradual increase of Population in urban area may leads to environmental pollution and microbial infection in air and water increases exponentially. Most of the persons in the population are in trap of mental stress and depression due to struggle in the life and overload of work. So both of these conditions are responsible for so many disease and ill-health, and one more important thing is that due to increase negligence and uninhabited use of processed food, the ill effects on health are compound manifold when coupled with unhealthy lifestyle and food habits. So there is a need of taking dietary supplementary food or nutraceutical. The main aim of Ayurveda has been working upon a twofold process i.e., to maintain the health of a healthy individual and to treat the one with the disease. Thus by laying emphasis on the first aspect and combining it with the knowledge of the role of phytochemical as, one can gradually deduce an effective module for living healthy and line of treatment of metabolic and geriatric disorders. The phytochemical are the essential nutrients, which are naturally contained in plants and are required for normal physiological functions. The Rasayan not only boost general health but also provide the necessary raw materials to strengthen the defense mechanism of the body.

Gastroprotective Activity of Methanol Leaves Extract of Barleria prionitis Linn. on Ethanol and Indomethacin Induced Ulcer in Rats.

Aims: Barleria prionitis L. (Family Acanthaceae) is a medicinal plant found road side in India and whole plant or its various parts like leaves, root, bark, stem and flowers are used traditionally for various treatments like toothache, inflammation, boils, glandular swellings and ulcer. Leaf juice is useful in gastric ulcer. Here, we attempt to prove the use of this plant as gastroprotective agent. Study Design: This study was conducted to evaluate the antiulcer activity of methanol extract obtained from the leaves of Barleria prionitis Linn. Place and Duration of Study: The experiments were conducted at Pharmacology lab of Institute of Pharmaceutical Sciences, Kurukshetra University during the period of July 2012 to December 2012. Material and Methods: Antiulcer activity was performed using the protocols of ulcer induced by ethanol and indomethacin at two different doses (250 and 500mg/kg). Parameters like volume of gastric juice, pH, free acidity, total acidity, aspartate amino transferase (AST) and alanine amino transferase (ALT) were also determined in ethanol induced ulcer model. Results: The reduction in ulcer index in Barleria prionitis treated animals was found to be statistically significant (P=.05), when compared with control groups in both the models. Significant changes were observed in total acidity only at dose 500mg/kg only and changes were significant in AST, ALT levels at both the doses. Other parameters showed non-significant results. Conclusion: The results of the present study show that the methanolic extract of Barleria prionitis L. possess antiulcer activity. This work supports the traditional use of this plant in treating gastric ulcer.

Effect of physico-chemical treatments on ripening behavior and post- harvest quality of Amrapali mango (Mangifera indica L.) during storage.

An experiment was done to assess the effect of various physico-chemical treatments on ripening behavior and post harvest quality of mango cv. Amrapali. The experiment was planned under completely randomized design (CRD ) with three replications. The treatment units was five fruits per replication. Total 14 treatments were applied. Out of these, ethrel 750 ppm treated fruits showed better results in respect of specific gravity (0.88), moisture loss (8.45%), decay (2.5%), total soluble solids (TSS, 20.7o brix), sugar content (14.39%) and acidity content (0.32) followed by ethrel 500 ppm; specific gravity (0.90), moisture loss (8.82%), decay (3.5%), TSS (20.7o brix ), sugar content (13.99%) and acidity content (0.36%). The pedicellate fruits and ethrel+bavistin (750+1000 ppm) were also found to be significantly superior over control in respect of specific gravity (0.88 and 0.86), moisture loss (9.10 and 9.33%), decay (4.0 and 5.33%), TSS (20.1 and 20.4o brix), sugar content (12.70 and 12.80%) and acidity content (0.42 and 0.38%), respectively. Based on results of this study, it can be concluded that ethrel 750 ppm was found to be the most suitable treatment in improving physico-chemical traits i.e. ripening, storage, quality and shelf-life for commercial purpose in mango.

Antidiabetic and antihyperlipidemic effects of Dillenia indica (L.) leaves extract / Efeitos antidiabético e anti-hiperlipidêmico de extratos de folhas de Dillenia (L. )

The present study was carried out to evaluate antidiabetic and antihyperlipidemic effects of Dillenia indica methanolic leaves extracts in streptozotocin induced diabetic Wistar rats by administering graded oral doses (250 and 500 mg/kg body weight) for 21 days. The extract showed significant antidiabetic activity (p<0.001). Furthermore, the decreased body weight of rats was significantly improved after extract treatments. Daily oral treatment with the extract for 21 days to diabetic rats, also resulted in significant reduction in serum cholesterol, triglycerides and serum transaminase levels but HDL-cholesterol level was found to be improved (p<0.001) as compared to the diabetic control group. The extract treatment also showed to enhance serum insulin level in diabetic rats as compared to the diabetic control group. In conclusion, D. indica leaf extract might be useful for diabetes mellitus management and other abnormalities associated with this metabolic disorder.

Realizou-se o presente estudo para avaliar os efeitos antidiabético e anti-hiperlipidêmico de extratos metanólicos de folhas de Dillenia indica em ratos wistar com diabetes induzido por estreptozotocina por meio da administração de doses orais (250 e 500 mg/kg de peso corporal) por 21 dias. O extrato mostrou atividade antidiabética significativa (p<0,001). Além disso, a diminuição do peso corporal dos ratos foi significativamente melhorada após o tratamento com os extratos. O tratamento com doses orais do extrato por 21 dias aos ratos diabéticos também resultou em redução significativa do colesterol, triglicerídios e níveis de transaminase séricos, mas o nível de HDL-colesterol foi melhorado (p<0,001), quando comparado ao grupo controle diabético. O tratamento com extrato também mostrou aumento do nível sérico de insulina em ratos diabéticos comparativamente ao grupo controle diabético. Em conclusão, o extrato de folha de D. indica poderia ser útil para o controle do diabetes mellitus e de outras anormalidades associadas a essa disfunção metabólica.

Comparison of Ziehl Neelsen and Auramine O staining methods on direct and concentrated smears in clinical specimens.

Background: In developing countries like ours with a large number of tuberculosis (TB) cases and limited resources, the diagnosis of TB relies primarily on smear microscopy for Acid Fast Bacilli (AFB) but its sensitivity is limited in paucibacillary cases. Aim: To evaluate the increase in efficacy of smear microscopy when smears are prepared from clinical samples after concentration by Petroff’s method and stained by Auramine O (AO) fluorescent dye as against Ziehl Neelsen (ZN) staining of similar taking culture as the gold standard. Methods: Smears were prepared from 393 clinical samples both by direct and after Petroff’s concentration and examined by fluorescent microscopy and Ziehl Neelsen method .The concentrated material was also cultured on Lowenstein Jensen media and the results of the two microscopy methods were compared with the culture results taken as the gold standard. Results: Mycobacterial growth was detected in 137(35.77%) specimens, out of which three were non-tubercular mycobacteria. Using culture as the reference method, the sensitivity of direct staining was 55.55% for ZN and 71.85% for AO. Direct fluorescent microscopy detected 9.29% paucibacillary sputum samples that were missed on ZN staining. On concentration, the sensitivity increased by 6.67% for ZN and 11.11% for AO. The sensitivity of AFB smear microscopy increased by 27.41% and was statistically significant (p=<.001) when both methods were combined. The specificity was 99.19% for both ZN and AO. Conclusion: Fluorescent microscopy has higher sensitivity and comparable specificity which is further enhanced by concentration. Now with the advent of newer inexpensive Light Emitting Diode (LED) based fluorescent microscopes (FM), which are easier to use, fluorescent microscopy can be widely used even in peripheral laboratories where culture facilities are not available.

Landry-Guillaine-Barré syndrome as presentation of celiac disease.

Celiac disease has been associated with a variety of neurological illnesses, most frequently cerebellar ataxia and peripheral neuropathy. We report presentation as Landry-Guillaine-Barré syndrome in a 28-year-old woman with previously unsuspected celiac disease.

Técnicas avançadas de sensoriamento remoto aplicadas ao estudo de mudanças climáticas e ao funcionamento dos ecossistemas amazônicos / Advanced remote sensing techniques for global changes and Amazon ecosystem functioning studies

Este artigo se propõe a apresentar exemplos de questões científicas que puderam ser respondidas no contexto do Projeto LBA (Large Sale Biosphere-Atmosphere Experiment in Amazonia) graças à contribuição de informações derivadas de sensoriamento remoto. Os métodos de sensoriamento remoto permitem integrar informações sobre os vários processos físicos e biológicos em diferentes escalas de tempo e espaço. Nesse artigo, são enfatizados aqueles avanços de conhecimento que jamais seriam alcançados sem a concorrência da informação derivada de sensoriamento.